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How Psychedelics Affect The Brain
What Do Psychedelic Drugs Do To The Brain?
Ecclesiastes 3:1 "To every thing there is a season, and a time to every purpose under the heaven"
Quick shout out to 60 Minutes, who put out an episode about psychedelic treatments for PTSD. Here is that link: https://youtu.be/O-5mpzNuGv0?si=Zu3kZDGvB96U2hdJ Please share on your social media =) ALSO!: I've put together an multiple choice quiz with an answer key and academic sources to prove these are real facts. If you're interested in taking the quick, here is the url: Psychedelics/Neuroscience Quiz/Test, 24 Questions
Serotonergic Psychedelics: Serotonergic psychedelics affect the 5-HT2A receptors, found predominantly in cortical regions of the brain.[7] What are cortical regions of the brain? Answer: "It is the gray matter of the brain. Lying right under the meninges, the cerebral cortex divides into four lobes: frontal, temporal, parietal and occipital lobes, each with a multitude of functions."[10] Common Serotonergic psychedelics include things like LSD(and natural lysergics like LSA/LSH, etc), Psilocybin(4-po-DMT)[and Psilocin(4-HO-DMT).[7][8][9] O.G. Observations & Thoughts: I'm not sure why scholars always list LSD instead of the natural versions of this research chemical(yes LSD was a research chemical back in the day). They always leave out LSA, LSH, and other natural lysergics, as if they don't count. Ergot and HBWR came before LSD, not the other way around. Moving on...
The cortical areas of the brain: The Frontal Lobe Area's Of The Brain: The Patietal Lobes: The Occitiptal Lobes:
Because we know that serotonergic psychedelics affect the 5-HT2A receptors found in predominantly the cortical regions of the brain(the cerebral cortex), I decided to go ahead and give my readers more information on these areas of the brain. For the sake of self diagnosis, these facts can help one determine which area of their brain is being affected by whatever it is that's going into your body right now, or in the future. "Damage to any of the frontal lobe areas may lead to weakness and impaired execution of motor tasks of the contralateral side."[10] These facts can help you hone in on what the enemies covert drug warfare may be doing to your mind. Pay attention to toxic pharmakeia food additives and how they affect your mind and biology. Based on what I just shared about the frontal lobe areas, this tells me that Proplyene glyocol effects those area's of the brain, based on personal experience(It's a neurotoxin being covertly put into 'hemp' products). I expose that fact more on my Cannabis blog here. What I just shared, is what I mean by self diagnosis. We can learn a great deal on our own thanks to scholarly sources made available to the public on the world wide web, and we should make use of this and be grateful for it. Use scholarly discernment, and choose academic sources when surfing, or look for websites that cite them and back up their work, like mine. "The inferolateral areas of the dominant hemisphere (usually left side) of the frontal lobe are the expressive language area (Broca area, Brodmann areas 44 and 45), to which damage will result in a non-fluent expressive type of aphasia."[10] The National Library Of Medicine source goes on to state that the frontal lobes areas are also associated with: "higher functioning processing, such as regulating emotions, social interactions, and personality."[10]
In General, Psilocybin has been found by researchers to: "induce the suppression of alpha activity, decreased global connectivity, and increased brain entropy (i.e. brain signal diversity) in eyes-closed resting-state."[13] To better understand these scientific facts related to Psilocybin(4-PO-DMT), and how it affects the human mind, I decided to define what the alpha activity in the brain represents, and cite academic sources so we can be sure. "An alpha wave is defined as a type of brain wave that falls within the frequency range of 8-13 Hz. These waves are typically observed in relaxed states with minimal mental activity, especially during wakefulness."[14] I'm about to cite other studies that show Psilocybin increases connectivity in the brain.[18] Again, dose matters because of the Arndt Schultz Medical Rule[17] so I am wondering how these researchers got the results that they witnessed a "decrease in global connectivity". BINGO! I found it. According to Yale University: "A single dose of psilocybin, the active compound in “magic mushrooms,” given to mice prompted a long-lasting increase in the connections between neurons."[18] The url for that finding: https://news.yale.edu. When I see contradictions like this, I assume those doing the study were possibly being manipulative, or didn't know about the Ardnt Shulz Law, which I find puzzling.. Any beneficial substance can cause harm in too high of a dose, and any harmful substance can be medicinal in a small enough dose, and that's the Ardnt Shultz Medical Rule in my own words(paraphrased).[17] Studies show that Psilocybin induces a decreased in alpha and beta band, but an increase in delta and gamma frequencies.[13] I will discuss those brain wave states so we know exactly what is happening with this drug, and we will get to the mystery of why sources are contradictory on the connectivity claims.
Beta waves are defined as: "Beta waves are high-frequency, low-amplitude brain waves that are commonly observed in an awaken state. They are involved in conscious thought and logical thinking, and tend to have a stimulating effect. Having the right amount of beta waves allows us to focus."[21] Delta waves are defined as: "Delta waves are the slowest recorded brain waves in human beings. Delta waves are high-amplitude brain waves and are associated with deep sleep stages. The delta waves are also associated with different brain functions other than deep sleep, e.g., high frontal delta waves in awake subjects are associated with cortical plasticity."[20] Gamma waves are defined as: "Gamma Waves refer to neural oscillations in the frequency range of approximately 30–100 Hz. These waves indicate the synchronization of different nerve cells working together in a network to carry out specific cognitive or motor functions"[15] A very revealing fact about Gamma waves I feel indicates scientific evidence that the shamans beliefs about these types of substances turning up the volume on their sixth sense, and allowing them to commune with other-worldly beings(spirits) may have some scientific backing, at least in terms of the ESP enhancement part.. Here is that scholarly quote, "Gamma waves and fast rhythms likely play a role in neural communication, reflecting information from the external world to the brain"[16] The part that I find the most interesting about that quote is, "reflecting information from the external world to the brain". To me it is evidence that confirms indigenous beliefs about how the mushrooms amplify our "spiritual ears and eye".
To recap what we just learned in my own words, and what was just cited with academic sources in the previous paragraph(s).. Psilocybin has been scientifically proven to reduce alpha brain waves, which represent relaxed states with minimal mental activity, thus indicating an increase in mental activity. It also reduces beta brain waves which represent conscious thought and logical thinking, which also tend to have a stimulating effect, thus relaxing the user. Combine this with the increase in delta and gamma brain waves which represent deep sleep stages, and the fact that they're associated with cortical plasticity(which is a good thing), and we can start see how these specimens work. Again, to quote the scholarly source that I got that information from: "high frontal delta waves in awake subjects are associated with cortical plasticity"[20] Gamma also represents the synchronization of different nerve cells working together to carry out various cognitive functions, thus enabling the person experiencing them to have a heightened awareness of external information being processed by the brain. The user is put into a conscious state that is the same as deep sleep, except for they're awake, and the increase in delta and gamma waves I believe is responsible for the "sixth sense" being amplified. This is my interpretation of what we just learned. Remember also the fact that psilocybin affects the 5-HT2A receptor, which is tied in with the unconscious mind, the dreaming mind, imagination, formation of memories, etc.[1][2]
Temporal Lobes: "The temporal lobes are most commonly associated with processing auditory information and with the encoding of memory"[11] Another set of facts related to these lobes of the Temporal area of the brain, include: "Bilateral lesions in the amygdala such as in Herpes simplex encephalitis may cause Kluver-Bucy syndrome. In this syndrome, patients would experience dis-inhibited behavior such as hyperphagia, hypersexuality, and hyper-orality".[11] By the way, a legion in neuroscience is "A lesion is an area of tissue that has been damaged through injury or disease."(WebMD) This is very interesting information indeed. Hyperphagia is defined as: "The meaning of HYPERPHAGIA is abnormally increased appetite for consumption of food frequently associated with injury to the hypothalamus."(Merrian-Websters) Hyper-orality can be defined as: "Hyperorality is a condition characterized by an excessive preoccupation with oral sensations and behaviors, such as chewing, sucking, biting, swallowing, and excessive mouthing of objects."[12] We all know what hypersexuality is I hope, because it is an excessive preoccupation with things of a sexual nature(extremely high libido).
Parietal Lobes: "Areas in the parietal lobe are responsible for integrating sensory information, including touch, temperature, pressure and pain."[19] This would indicate to us which region of the brain is being messed with during experiences of synesthesia, which are commonly reported by those under the influence of psilocybin and other serotonergic psychedelics, including lysergics. Question: What is synesthesia? Answer: According to Darthmouth University, Synesthesia is "a rare neurological condition, describes an involuntary, automatic union of the senses or secondary experience caused by an external stimulus. The word “synesthesia” comes from the Greek meaning “to perceive together.”[22] What does the science show about how these psychedelic drugs affect the Parietal lobes though? "Recent imaging studies have found changes in functional coupling between frontal and parietal brain structures, suggesting a modification in information flow between brain regions during acute effects."[23] It goes on to state that: "Transfer entropy analysis showed that frontal sources decreased their influence over central, parietal, and occipital sites. Conversely, sources in posterior locations increased their influence over signals measured at anterior locations. Exploratory correlations found that anterior-to-posterior transfer entropy decreases were correlated with the intensity of subjective effects"[23] The study concludes that: "These results suggest that psychedelics induce a temporary disruption of neural hierarchies by reducing top-down control and increasing bottom-up information transfer in the human brain."[23] So we can see a recurring pattern of scholarly sources mentioning this increase in information transfer in the human brain, and this is very interesting and clues us in on what is happening neurologically during these experiences. Remember the other source I quoted that mentioned how the increase in gamma waves "indicates the synchronization of different nerve cells working together in a network to carry out specific cognitive or motor functions"[15]
Occipital Lobes: "The occipital lobe is the visual processing area of the brain. It is associated with visuospatial processing, distance and depth perception, color determination, object and face recognition, and memory formation."[24] This would explain why people see bright colorful lights under the influence of these drugs. One could say that their eyes were "stared by the flash of a neon light"(see sounds of silence by Simon and Garfunkel). DMT in particular, is especially visual, psilocybin as well, being a form of DMT(4-PO-DMT). After reading about the occipital lobes, it made me wonder about colors and their frequencies, and about the shamanic beliefs tied to these drugs.. If shamans believed that they were communicating with spirits under the influence of naturally occurring psychedelic substances, might these spirits be able to communicate to them with frequencies that the mind would register as colors? I think it would be cool to conduct some science experiments to see if color frequencies could be produced in alternative ways, like as sounds, to see if the mind under the influence of psilocybin could register those frequencies as colors. I hypothesize that the external world is being seen in a heightened state of external and internal awareness, and one that relies on more than just the two eyes, and instead incorporates all three(the pineal gland[minds eye], and then the regular two eyes, and then your additional sixth sense.) I guess you could say, "seeing without seeing", or "hearing without hearing". Have you ever heard of color psychology? A quote from an academic source on the subject states that: "The review clearly shows that color can carry important meaning and can have an important impact on people's affect, cognition, and behavior."[25] I'll discuss this topic more further on down the page.
The 5-HT2a Receptor, Its Functions, And How Psychedelics Interact With The Receptor System: Most psychedelics effect a part of the brain where a receptor cite called the 2a receptor can be found.[1] It is located in the part of the brain where major computational units in the brain exist, where all your unconscious stuff is, where your imagination, your memories and all of that, are all input into these special cells that processes the information.[1][2] What this basically tells me is our deepest mysterious and most latent and yet to be expressed potential of the mind is unlocked by these types of psychedelic drugs. They're like a key that opens a door. According to another academic source, "lysergic acid diethylamide (LSD) induces an altered state of consciousness that resembles dreaming."[3] This correlates with what researcher David Nichols was saying in the documentary. These substances turn on the hidden aspects of our psyche! These substances, such as naturally occurring lysergics, Psilocybin and other forms of DMT, mescaline, ibogaine, etc, are connected to both ethnobotany and Phytochemistry, and are critical in understanding how the mind works, thus the knowledge we gain from studying them is beneficial to breakthroughs in neuroscience.[4][5][6]
Color Psychology And How It Relates To Figuring Out The Mysteries Of Psilocybin's Effects On The Brain: Because we know that the Occipital lobes are where visuals are processed, we know that it relates to our sense of color.[24] Color psychology gives us a great glimpse into the mysteries of these "hieroglyphics of the Great I AM" as I like to call them.. Colors were invented by the creator, not the adversary, for his purpose, not the enemies. The truth is that colors communicate. I subscribe to the observations of the ancients, and that is that everything communicates, everything contains information, and everything is connected in some way, in that it shares a symbiotic relationship with everything else in existence outside of itself. Creation is the ultimate example of symbiosis. What is symbiosis? "Symbiosis is defined as a close, prolonged association between two or more different biological species"[27] Let's delve into a bit about what the science says, so we can unlock the scientific mysteries of these psychedelics, and how they relate to colors, and what those colors represent scientifically. "Color psychology sits at the intersection of color science and psychological science, and it is interesting to consider how color psychology is construed by each of these disciplines."[25] Did you know that many ancient cultures including shamans, alchemist, mystics, and others have all learned to identify the effects of plants by observing their appearance, color, and even their aroma.(Heaven, Charing 2006 13)[29] This all ties in with the ancient observed knowledge that is referred to as the "doctrine of signatures".[28] It is an observatory method for learning about Gods creation, by observing hidden truths that communicate to us the purpose of all things.(Ecclesiastes 3:1) While we are on the subject of the doctrine of signatures, I want to state an O.G. Observation: The fuzzy coating on REAL Agryeia nervosa seeds(HBWR) produce the same rich brownish/gold color that the standard B+ Psilocybin cubensis mushrooms produce! This is yet another example of the doctrine of signatures, as both of these ethnobotanical drugs work on the same 5-HT2A receptors and generally work the same, and are obviously both psychoactive. According to ancient wisdom:, Yellow on a plant was associated with the liver, blue was associated with nerves, orange with the spleen, white with bones.(Heaven, Charing 2006 13)[29][30] The shape of the leaves of the plant was also an indication as to what the plants properties were.(Heaven, Charing 2006 13)[29][30] A great example is how Cannabis sativa produces thin leaves and a more tall build, produces stimulating effects and a cerebral high[x].. Whereas indica is short, fat, and produces wide leaves, and a body high, and more of a sedative one than Sativa.[x]
Warning about M.A.P.S.
While I am all about research, I don't necessarily trust M.A.P.S. or its mission... I believe they're going to do what they always do, and turn natural psychedelics into weird man-made pharmaceuticals, and they will not have the same divine properties once man intervenes and ruins their molecular structure, thus tainting their once miraculous pharmacology. We can already see evidence of this, as schedule35.co is selling "magic mushroom products", which are illegal, so how are they not getting raided?. I don't believe that the schedule35.co products are authentic psilocybin from mushrooms, rather I believe they're a synthetic version made in a lab. I tried some years ago and I can tell you that they're fake. I tested the schedule35.co products years ago, for the sake of providing intel, and took a very small dose.. Let's just say I had a vision of a serpent and could tell that it wasn't authentic psilocybin. Micro-supply.com has the real Psilocybin mushroom spores for microscope research, and they're legal. The spores are legal to own, but not to grow. EarthsTongue also has supplies for mushroom enthusiasts, of all kinds. The url loads on my phone, but not my laptop for some reason.This is random, but this is a great performance. This is the type of music that indigenous cultures would make and utilize in combination with psychedelic ethnobotanicals such as psilocybin and others. The drugs combined with these deep meditative practices can take one on a journey. Protect yourself from spiritual forms of wickedness in all that you do, and direct your worship and service not to idols but to the real creator, the great "I AM". Psalm 91:1 but also avoid discrimination, avoid religious bullying, and respect others belief systems and right to belief and practice what they want in America. Anyway, here is that performance: OLox - A Neo-Shamanic Transformative Journey Through Arctic Sounds | Bioneers
Related HerbsPedia Blogs: Tabernanthe iboga(Ibogaine plant), Pharmaceutical industry to rob America of ibogaine(iboga) and replace with pharmakeia, MDMA precursors in the ethnobotanical market, legal, Argyreia nervosa seeds(LSA/LSH) LSD Precursors(legal!), Plants That Produce/Contain LSA/Ergot Constituents, LSA producing seeds connected to illegal LSD labs, Ololiuqui are another lysergic source, utilized by the indigenous culture of Oaxaca Mexico., Plants That Produce Ketamine, Plants That Produce DMT, Plants And Cactus That Produce Mescaline, List Of Scopolamine producing ethnobotanicals, List Of Ibogaine Producing Plants, List Of Medical Terms And Definitions, Legal Ethnobotanical Methamphetamine Precusors Exposed, Acacia berlandieri plant produces methamphetamines, Corrupt Ethnobotanical Industry Exposed, Occult Crime Rings/Alladin Cheaters, Bella Donna(Deadly Nightshade) Occult/Big Pharma Connection Exposed
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Academic citations:
[1] Hamiltons Pharmacopeia Season 3 Episode 6 (Hamilton is an academic researcher and journalist) [https://youtu.be/E-t84yicaOE?si=GXE4IbPticyyT8MR]
[2] Psychedelic Researcher David E Nichols. https://en.m.wikipedia.org/wiki/David_E._Nichols#:~:text=Nichols%20is%20one%20of%20the,effects%20are%20described%20in%20TiHKAL.
[3] Kraehenmann, Rainer, et al. "Dreamlike effects of LSD on waking imagery in humans depend on serotonin 2A receptor activation." Psychopharmacology 234 (2017): 2031-2046.
[4] Presley, Christopher C., and Craig W. Lindsley. "DARK classics in chemical neuroscience: opium, a historical perspective." ACS chemical neuroscience 9.10 (2018): 2503-2518.
[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC10634557/ Cameron LP, Benetatos J, Lewis V, Bonniwell EM, Jaster AM, Moliner R, Castrén E, McCorvy JD, Palner M, Aguilar-Valles A. Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action. J Neurosci. 2023 Nov 8;43(45):7472-7482. doi: 10.1523/JNEUROSCI.1384-23.2023. PMID: 37940583; PMCID: PMC10634557.
[8] Glatfelter, Grant C., et al. "Receptor binding profiles for tryptamine psychedelics and effects of 4-propionoxy-N, N-dimethyltryptamine in mice." ACS Pharmacology & Translational Science 6.4 (2023): 567-577.
[9] Mishraki‐Berkowitz, Tehila, et al. "The psilocin (4‐hydroxy‐N, N‐dimethyltryptamine) and bufotenine (5‐hydroxy‐N, N‐dimethyltryptamine) case: ensuring the correct isomer has been identified." Journal of Forensic Sciences 65.5 (2020): 1450-1457.
[10] Javed K, Reddy V, Lui F. Neuroanatomy, Cerebral Cortex. [Updated 2023 Jul 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537247/
[11] https://www.health.qld.gov.au/abios/asp/btemporal_lobes
[12] https://www.ncbi.nlm.nih.gov/medgen/325386
[13] Nikolic, Marek, et al. "Psilocybin alters brain activity related to sensory and cognitive processing in a time-dependent manner." medRxiv (2024): 2024-09.
[14] https://www.sciencedirect.com/topics/neuroscience/alpha-wave
[15] https://www.sciencedirect.com/topics/neuroscience/gamma-wave
[16] https://pubmed.ncbi.nlm.nih.gov/18439878/
[17] Sharma, Rajneesh Kumar. "Arndt Schultz Law and Its Applications."
[18] https://news.yale.edu/2021/07/05/psychedelic-spurs-growth-neural-connections-lost-depression
[19] https://qbi.uq.edu.au/brain/brain-anatomy/lobes-brain
[20] https://www.sciencedirect.com/topics/neuroscience/delta-wave
[21] https://www.sciencedirect.com/topics/medicine-and-dentistry/beta-wave
[22] https://sites.dartmouth.edu/dujs/2013/03/05/what-is-synesthesia/
[23] https://pmc.ncbi.nlm.nih.gov/articles/PMC4571623/
[24] https://www.ncbi.nlm.nih.gov/books/NBK544320/
[25] Elliot, Andrew J., and Markus A. Maier. "Color psychology: Effects of perceiving color on psychological functioning in humans." Annual review of psychology 65.1 (2014): 95-120.
[27] https://www.pbs.org/articles/what-is-symbiosis
[28] National Park Service | https://www.nps.gov/glac/learn/education/native-american-plant-use.htm
[5] Balick, Michael J., and Paul Alan Cox. Plants, People, And Culture : The Science Of Ethnobotnay. New York, Garland Science, 2020.
[6] Tyler, Varro E, et al. Pharmacognosy. 1988 (9th Edition)
[29] Heaven, Ross, and Howard G. Charing. Plant spirit shamanism: Traditional techniques for healing the soul. Simon and Schuster, 2006.
[30] Clark, L. A. (1975). The ancient art of color therapy: Updated, including gem therapy, auras, and amulets. Old Greenwich, CT: Devin-Adair.
Encyclopedia Sources:
Other resources:
M.A.P.S. Ethnobotanical Studies By Scholars
PubChem - pubchem.ncbi.nlm.nih.gov
Neurosoup.com Huge Drug Database